Page 11 - SAM September 2019
P. 11

PUBLIC HEALTH

        Graph 1

                                                                 Graph 2


























        sally  used  as  spices  considered  fit  for  Graphs 1 and 2 display the enhanced ef-  additive or synergistic combination.
        human consumption.                   ficacy against s.epidermidis when plant ex-  Therefore, while it is important to recog-
          Plant extracts are also popular for their  tracts  are  combined  with  Gentamicin,.  nize  the  importance  of  pharmaceutical
        low toxicity and rare complications, com-  Certain  concentrations  may  double  the  therapy in specific diseases, it is important
        pared with some medications. The lower  zone of inhibition, which shows great po-  to stress the importance of a good diet as
        number of adverse effects make them safer.  tential. It is evident that garlic and ginger  an additive to rather than a replacement for
        Garlic possesses a material called Allicin,  enhance  the  effect  of  Gentamicin,  with  certain treatments. This is clearly illustrated
        which is a strong oxidizing component that  their bacterial growth inhibition becoming  when adding raw garlic and ginger to one’s
        disables the bacterial associated enzymes  stronger. An important extension of this  diet regime when taking an anti-biotic.
        (that are necessary for infections to occur)  study would be to investigate the molecular
        by altering the membrane of the bacterium.  mechanism that allows Gentamicin to dis-  Abdullah Ghali is a second year Medical Stu-
        As for Ginger, the mechanism of action in-  play a larger zone of inhibition. This would  dent at the University of  Texas Health Science
        volves inhibition of enzymes essential for  then indicate whether the combination of  Center in San Antonio.
        fatty acid metabolism.               Gentamicin and garlic/ginger produces an




        References
        1. Agu V, Jibo S, Adeshina G. 2012. Antibacterial  Jersey: Wiley-Blackwell. 179 p.  tion of antibacterial mode of action of Allium
           Susceptibility Pattern of Pathogenic Bacteria  6. Kim SO, Kundu JK, Shin  YK. 2005. [6]-Gin-  sativum  essential  oil  against  foodborne
           Isolates from Vegetable Salad Sold in Restau-  gerol inhibits COX-2 expression by blocking  Pathogens using Membrane permeability and
           rants in Zaria, Nigeria. Journal of Microbiology  the activation of p38 MAP kinase and NF-kap-  surface characteristic parameters. J. Food Saf
           Research 2(2): 5-11 p.              paB in phorbol ester-stimulated mouse skin..  33(2): 197-208
        2. Astrographics,  2005.  E.  Coli  Bacterium.  US National Library of Medicine National In-  10. Sihota R, Tandon R. 2011. Parsons' Diseases
           www.astrographics.com/GalleryPrintsIndex/G  stitutes of HealthSearch database [Internet].  of the Eye. Haryana: Elsevier BV. 148 p.
           P2144.html. Accessed 2013 July 17.  [2012 Mar 14, cited 2013 Oct 14] 24(15):2558-  11. World Health Organization, 2004.  Antimicro-
        3. Drugs, 2012. Common Side Effects, Allergies  67.  Available  from:  www.ncbi.nlm.nih.gov/  bial  Resistance.  www.who.int/mediacentre/
           and Reactions to Antibiotics. www.drugs.com/  pubmed/15735738            factsheets/fs194/en. Accessed 2013 October 27.
           article/antibiotic-sideeffects-allergiesreac-  7. Nievergelt A. 2011. In vitro immunopharma-  12. Ziarlarimi A, Irani M, Gharahveysi S, Rahmani
           tions.html. Accessed 2013 August 22.  cological profiling of ginger (Zingiber offici-  Z. 2011. Investigation of antibacterial effects
        4. Feldberg  R,  Chang  S,  Kotik  A,  Nadler  M,  nale Roscoe).[Internet]. [Cited 2013 Sep 11].  of garlic (Allium sativum), mint (Menthe spp.)
           Neuwirth  Z,  Sundstorm  D,  Thompson  N.  Available  from:  https://e-collection.library.  and onion (Allium cepa) herbal extracts on Es-
           1988. In Vitro Mechanism of Inhibition of  ethz.ch/eserv/eth:4650/eth-4650-01.pdf  cherichia coli isolated from broiler chickens.
           Bacterial Cell Growth by Allicin. Antimicrobial  8. Peter,  K.  2004.  Handbook  of  Herbs  and  African  Journal  of  Biotechnology  10(50):
           agents and chemotherapy 32(12): 1763-1768.  Spices.  Volume 2. Cambridge: Woodhead pub-  10320-10322 p.
        5. Keen P, Montforts M. 2012. Antimicrobial Re-  lishing. 33 p.
           sistance in the Environment. Hoboken, New  9. Sharma A, Bajpai V, Baek K. 2013. Determina-


                                                                                               visit us at www.bcms.org  11
   6   7   8   9   10   11   12   13   14   15   16