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OPIOID CRISIS

like oxycodone or heroin if used concurrently. These medications                 Depressant Effects of Morphine. Neuropsychopharmacology,
can also cause withdrawals from suddenly discontinuation, just like              2016. 41(3): p. 762-73.
other opioids, but this can be beneficial by encouraging continuation         4. Ling, G.S., et al., Differential development of acute tolerance to
of the maintenance therapy.                                                      analgesia, respiratory depression, gastrointestinal transit and hor-
                                                                                 mone release in a morphine infusion model. Life Sci, 1989.
  Opioid receptor antagonists like naltrexone have been used as                  45(18): p. 1627-36.
well, but with less encouraging results (19). These patients need             5. American Psychiatric Association, Diagnostic and Statistical Man-
to be motivated to abstain from using opioids, as cessation of nal-              ual of Mental Disorders. 5th ed. 2013, Washington, DC.
trexone will not precipitate withdrawals like with opioid agonist             6. Centers for Disease Control and Prevention. Opioid Overdose:
therapy. This leads to poorer adherence to the treatment, and thus               Prescribing data. [Web page] 2016 December 20, 2016 [cited 2017
higher rates of relapse.                                                         July 3]; Available from: https://www.cdc.gov/drugoverdose
                                                                                 /data/prescribing.html.
  Counseling and therapy groups are helpful treatment options as              7. Rudd, R.A., et al., Increases in Drug and Opioid Overdose
well, with approaches such as motivational interviewing, cognitive               Deaths--United States, 2000-2014. MMWR Morb Mortal Wkly
behavioral therapy in either an inpatient or outpatient setting being            Rep, 2016. 64(50-51): p. 1378-82.
shown to reduce relapse. Typically, these approaches work best in             8. Rudd, R.A., et al., Increases in Drug and Opioid-Involved Over-
conjunction with pharmacologic methods to enhance outcomes and                   dose Deaths - United States, 2010-2015. MMWR Morb Mortal
results (19).                                                                    Wkly Rep, 2016. 65(5051): p. 1445-1452.
                                                                              9. Johannes, C.B., et al., The prevalence of chronic pain in United
Conclusions:                                                                     States adults: results of an Internet-based survey. J Pain, 2010.
  The opioid epidemic, while now recognized as a significant prob-               11(11): p. 1230-9.
                                                                              10.Pain terms: a list with definitions and notes on usage. Recom-
lem in the United States, continues to grow yearly. Though opioids               mended by the IASP Subcommittee on Taxonomy. Pain, 1979.
themselves can be useful for a variety of pain conditions in patients            6(3): p. 249.
with specific diagnoses, their use should be limited to those cases           11.OxyContin Marketing Plan, 2002. 2002, Purdue Pharma: Stam-
where other options have been attempted unsuccessfully. Using ap-                ford, CN.
propriate monitoring, such as urine drug screens and prescription             12.Van Zee, A., The promotion and marketing of oxycontin: com-
access databases, is highly recommended. Attempts should also be                 mercial triumph, public health tragedy. Am J Public Health, 2009.
made to use the lowest doses possible, and wean the patient when                 99(2): p. 221-7.
treatment has failed or is no longer needed. Unfortunately, prescrip-         13.Porter, J. and H. Jick, Addiction rare in patients treated with nar-
tion opioids are many normal people’s first foray into addictive sub-            cotics. N Engl J Med, 1980. 302(2): p. 123.
stances, and many times, this occurs unintentionally after an injury          14.Leung, P.T.M., et al., A 1980 Letter on the Risk of Opioid Ad-
or surgery for which opioids were prescribed, perhaps for longer                 diction. New England Journal of Medicine, 2017. 376(22): p.
than recommended with the newest guidelines. Without proper ed-                  2194-2195.
ucation and precautions, many of these people begin to misuse the             15.Meier, B. In guilty plea, OxyContin maker to pay $600 million.
medications and eventually become addicted. Ultimately, physicians               New York Times, 2007.
should be the first line of defense by limiting their prescribing to          16.Cicero , T.J., M.S. Ellis , and H.L. Surratt Effect of Abuse-De-
appropriate cases for the good of our patients and their families.               terrent Formulation of OxyContin. New England Journal of
                                                                                 Medicine, 2012. 367(2): p. 187-189.
               Dr. Brian Boies is an Assistant Professor in the Department    17.Dowell, D., T.M. Haegerich, and R. Chou, CDC Guideline for
            of Anesthesiology at the University of Texas Health Science Cen-     Prescribing Opioids for Chronic Pain--United States, 2016.
            ter at San Antonio (UTHSCSA), and is board-certified in both         JAMA, 2016. 315(15): p. 1624-45.
            Pain Medicine and Anesthesiology.                                 18.Shah, A., C.J. Hayes, and B.C. Martin, Characteristics of Initial
                                                                                 Prescription Episodes and Likelihood of Long-Term Opioid Use
Works Cited:                                                                     - United States, 2006-2015. MMWR Morb Mortal Wkly Rep,
1. Volkow, N.D. and A.T. McLellan, Opioid Abuse in Chronic Pain                  2017. 66(10): p. 265-269.
                                                                              19.Tetrault, J.M. and J.L. Butner, Non-Medical Prescription Opioid
   — Misconceptions and Mitigation Strategies. New England Jour-                 Use and Prescription Opioid Use Disorder: A Review. Yale J Biol
   nal of Medicine, 2016. 374(13): p. 1253-1263.                                 Med, 2015. 88(3): p. 227-33.
2. Miguez, G., M.A. Laborda, and R.R. Miller, Classical conditioning
   and pain: conditioned analgesia and hyperalgesia. Acta Psychol
   (Amst), 2014. 145: p. 10-20.
3. Hill, R., et al., Ethanol Reversal of Tolerance to the Respiratory

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